The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control

Rambam Health Care Campus

Status: Completed

Conditions: Healthy

Treatments: Drug: Duloxetine

Study type: Interventional

Funder types: Other

Identifiers

NCT00660751

DNIC01CTIL

Details and patient eligibility

About

The role of central serotonergic and adrenergic systems in the effectiveness of DNIC (Diffuse Noxious Inhibitory Control) will be tested before and after taking Duloxetine and Placebo in a double blind study.

Enrollment: 64 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• age 18-80
• no chronic disease

Exclusion criteria

• Subjects who suffer from chronic pain / pain syndrome
• use of anti-depressant or anti-psychotic drugs
• food/ drugs sensitivity
• breast feeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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64 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Treatment:

Drug: Duloxetine

2

Placebo Comparator group

Treatment:

Drug: Duloxetine