The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis

Aristotle University Of Thessaloniki

Status and phase: Unknown; Early Phase 1

Conditions: Vestibular Neuritis

Treatments: Drug: Corticosteroids; Other: Vestibular exercises

Study type: Interventional

Funder types: Other

Identifiers

NCT01231009

VN-01-JG

Details and patient eligibility

About

Aim of present study is to determine whether corticosteroids and vestibular exercises are equal effective in the recovery of balance in patients with acute vestibular neuritis.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with history of acute or sub-acute rotatory vertigo with postural imbalance, nausea and imbalance.
• Horizontal-rotatory spontaneous nystagmus.

Exclusion criteria

• History of vestibular disfunction before the acute onset of symptoms
• Simultaneous Hearing loss
• Neurologic disorder
• Pregnancy or lactation
• History of psychiatric disorders
• History of glaucoma
• Diabetes
• Hypertension
• Contraindication in receiving corticosteroids

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

Corticosteroids

Active Comparator group

Description:

Patients receive for 7 days intravenous corticosteroids, dexamethasone, and they continue receiving for 7 days corticosteroids per os

Treatment:

Other: Vestibular exercises

Drug: Corticosteroids

Vestibular exercises

Placebo Comparator group

Description:

Patients perform for 15 days certain vestibular exercises under suspicion of an expert physiotherapist

Treatment:

Other: Vestibular exercises

Drug: Corticosteroids