The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content (LICARB)

Hvidovre University Hospital

Status

Completed

Conditions

Diabetes

Overweight and Obesity

NAFLD

Metabolic Syndrome

Treatments

Other: Low Carb High Fat Diet

Other: High Carb Low Fat Diet

Study type

Interventional

Funder types

Other

Identifiers

NCT04581421

LICARB ID PhD010-19.

Details and patient eligibility

About

The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.

Full description

Overweight but otherwise healthy men will be included in the study which is a randomized diet intervention study in a cross over design.

The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.

Enrollment

12 patients

Sex

Male

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men being 18-50 years old.
Overweight (BMI 25-35)
Low to moderate physical activity level, defined as ≤ 1 weekly session of aerobic exercise.
Non-smokers
No use of medicine

Exclusion criteria

Fasting blood glucose indicating overt diabetes (≥7 mmol/l)
HbA1C >48 mmol/mol
Fasting plasma triacylglycerol indicating dyslipidemia (≥2.2 mmol/l)
FIB-4 score >1.45
Contraindications for MR-scan: abdominal height exceed limitations of the MR-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia.