The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

University Hospital Basel

Status: Completed

Conditions: Exploratory Behavior

Treatments: Dietary Supplement: 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39; Dietary Supplement: 25g Fructose in 300ml tap water; Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole; Dietary Supplement: 300ml tap water with 450ppm lactisole; Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube; Dietary Supplement: tap water

Study type: Interventional

Funder types: Other

Identifiers

NCT01918566

EKBB 298/12

Details and patient eligibility

About

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• right-handed healthy males, no drugs, non-smoking

Exclusion criteria

• drug abuse, smoker, left-handed, claustrophobia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 6 patient groups, including a placebo group

300ml tap water

Placebo Comparator group

Description:

Single intragastric instillation of 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: tap water

Glucose

Active Comparator group

Description:

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Glucose plus Lactisole

Active Comparator group

Description:

Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole

Treatment:

Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole

Fructose

Active Comparator group

Description:

Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: 25g Fructose in 300ml tap water

Glucose and Exendin

Active Comparator group

Description:

Single intragastric instillation of 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39

Treatment:

Dietary Supplement: 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39

tap water, lactisole

Sham Comparator group

Description:

Single intragastric instillation of 300ml tap water with 450ppm lactisole

Treatment:

Dietary Supplement: 300ml tap water with 450ppm lactisole