The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

The University of Alabama at Birmingham

Status: Completed

Conditions: Chronic Kidney Failure; Endothelial Dysfunction; Hemolytic-uremic Syndrome (HUS); Acute Renal Failure

Study type: Observational

Funder types: Other

Identifiers

NCT00358306

F070309010

Details and patient eligibility

About

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Full description

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Enrollment: 36 patients

Sex: All

Ages: 2 to 20 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children between age 2-20
• Decrease in renal function by 25% or greater
• Renal function has returned to normal

Exclusion criteria

• History of chronic disease
• Cancer
• Congenital heart disease
• Organ Transplantation
• Liver disease
• Pulmonary disease
• Diabetes other primary metabolic condition
• Severe neurologic impairments
• Hypertension
• Auto-immune
• Infectious disease or renal disease
• Smokers
• Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
• severe allergies including allergy to seafood and/or iodine

Trial design

36 participants in 1 patient group

a

Description:

those with previous history of Acute kidney injury