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The Role of Exercise Training in the Treatment of Resistant Hypertension (EnRIcH)

A

Aveiro University

Status

Completed

Conditions

Resistant Hypertension

Treatments

Other: Exercise Group

Study type

Interventional

Funder types

Other

Identifiers

NCT03090529
1725/2014

Details and patient eligibility

About

The main purpose of this study is to assess whether exercise training reduces ambulatory blood pressure in patients with resistant hypertension. To accomplish these goals 60 patients with resistant hypertension will be recruited and randomized into exercise training or control groups and followed up for 6 months. The patients in the exercise group will participate in a 3-month outpatient program. The control group will receive usual medical care. At baseline, after the intervention and 3 months after the end of the intervention both groups will undergo several evaluations, including casual and ambulatory blood pressure, body composition, cardiorespiratory fitness, quality of life, arterial stiffness, autonomic function, and endothelial and inflammatory biomarkers.

Enrollment

60 patients

Sex

All

Ages

40 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: confirmed resistant hypertension, who in the previous 3 months had unchanged medication

Exclusion Criteria:

  1. Patients with secondary hypertension
  2. Evidence of target organ damage
  3. Patients with heart failure
  4. Previous cardiovascular event
  5. Peripheral artery disease
  6. Renal failure
  7. Chronic obstructive pulmonary disease
  8. Systolic office blood pressure superior to 180 mmHg
  9. Biomechanical limitations to physical activity
  10. Those participating in regular physical activity

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

60 participants in 2 patient groups

Exercise group
Experimental group
Description:
The 12-week exercise-training program will include three sessions of aerobic exercise per week
Treatment:
Other: Exercise Group
Control group
No Intervention group
Description:
The control group will receive usual medical care

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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