The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Sheba Medical Center

Status: Unknown

Conditions: IDIOPATHIC PULMONARY FIBROSIS

Study type: Observational

Funder types: Other

Identifiers

NCT01714934

SHEBA-12-9440-TS-CTIL

Details and patient eligibility

About

The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging. Pepsin is a proteolytic enzyme present in the gastric juice. Microaspirations of gastric content were described as a potential factor for injury in many chronic lung disorders. Bronchoalveolar lavage (BAL) is a routine investigation technique in interstitial lung diseases. The presence of pepsin in the BAL fluid recovered from patients with IPF may indicate a possible role for gastric microaspirations in the pathogenesis of the disease.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with interstitial lung disorders including IPF

Exclusion criteria

• patients younger than 18 years or older than 85,
• pregnant women,
• patients that present with medical conditions contra -indicated for performing bronchoscopy including sedation

Trial design

40 participants in 2 patient groups

IPF

Description:

IPF patients diagnosed according to clinical and radiological findings

NON IPF

Description:

Other interstitial lung diseases such as sarcoidosis or hypersensitivity pneumonitis diagnosed as per clinical and radiological findings