The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

Asfendiyarov Kazakh National Medical University

Status: Completed

Conditions: Idiopathic Osteoarthritis

Treatments: Genetic: SNP analysis of the DNA

Study type: Observational

Funder types: Other

Identifiers

NCT05095142

1191

Details and patient eligibility

About

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee

Enrollment: 500 patients

Sex: All

Ages: 18 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
2. Representatives of the Kazakh ethnic group up to the 3rd generation;
3. Hereditary history of arthrosis;
4. Persons who are able and willing to provide written informed consent;

Exclusion criteria

1. Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
2. Representatives of other ethnic groups;
3. Representatives of the Kazakh ethnic group less than 3 generations;
4. No family history of bilateral idiopathic gonarthrosis;
5. Patients with an acute period of the inflammatory process (laboratory and clinical signs);
6. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
7. Pregnant or lactating women;
8. Tuberculosis of any localization in the active phase and in history;
9. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
10. Severe and decompensated course of endocrine diseases;
11. Autoimmune diseases;
12. Systemic diseases;
13. Oncological diseases;

Trial design

500 participants in 2 patient groups

Experimental group:

Description:

patients with idiopathic osteoarthritis of the knee

Treatment:

Genetic: SNP analysis of the DNA

Control group

Description:

patients without idiopathic osteoarthritis of the knee

Treatment:

Genetic: SNP analysis of the DNA