The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population

Asfendiyarov Kazakh National Medical University

Status

Completed

Conditions

Idiopathic Scoliosis

Treatments

Genetic: SNP analysis of the DNA

Study type

Observational

Funder types

Other

Identifiers

NCT05095129

1192

Details and patient eligibility

About

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis

Enrollment

400 patients

Sex

All

Ages

4 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Persons with a doctor-confirmed diagnosis of idiopathic scoliosis;
Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;
Hereditary history of scoliosis;
Persons who are able and willing to provide written informed consent;

Exclusion criteria

Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age;
Representatives of the Kazakh ethnic group less than 3 generations;
No family history of bilateral idiopathic scoliosis;
Patients with an acute period of the inflammatory process (laboratory and clinical signs);
Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
Pregnant or lactating women;
Tuberculosis of any localization in the active phase and in history;
Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
Severe and decompensated course of endocrine diseases;
Autoimmune diseases;
Systemic diseases;
Oncological diseases;