The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease. (GUT-ACS)

University of Oslo (UIO)

Status: Unknown

Conditions: Intestinal Disease; Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04605627

Oslo University Hospital

Details and patient eligibility

About

Define a signature of gut microbiota composition and related metabolites in patients with ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic coronary disease (CAD).

Full description

A total of 200 patients, allocated to 50 patients with chronic coronary syndrome, 75 patients with non-ST elevation myocardial infarction and 75 patients with ST- elevation myocardial infarction will be included. Clinical information, blood samples and fecal samples will be collected. Fecal and blood samples will be collected once in patients With chronic disease and in patients with acute coronary syndrome; in the acute phase and after 3 months.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary heart disease verified by coronary angiography

Exclusion criteria

• Current infection requiring intravenous antibiotics
• Inflammatory bowel disease
• Renal failure with creatinine > 200µmol/L
• Hepatic impairment
• Pregnancy
• Previous bariatric surgery
• Colostomy
• Active malignant disease

Trial design

200 participants in 3 patient groups

Chronic coronary syndrome

Description:

50 patients with chronic coronary disease

Non ST segment-elevation myocardial infarction

Description:

75 patients with non ST-elevation myocardial infarction

ST-elevation myocardial infarction

Description:

75 patients with ST segment-elevation myocardial infarction