The Role of High-flow Nasal Cannula Therapy in the Treatment of Acute Carbon Monoxide Poisoning

Università degli Studi del Piemonte Orientale "Amedeo Avogadro"

Status: Unknown

Conditions: Carbon Monoxide Poisoning

Treatments: Device: High-flow nasal cannula device; Device: Non-rebreathing oxygen mask group

Study type: Interventional

Funder types: Other

Identifiers

NCT03818841

CO-HFNC

Details and patient eligibility

About

The aim of the study is to test whether oxygen therapy delivered through high-flow nasal cannula devices in patients admitted to the emergency department for acute carbon monoxide poisoning is superior to the non-rebreathing oxygen face mask therapy with a 15 L/minute oxygen flow (currently the first-line therapy), in terms of reduction of carboxyhemoglobin (COHb) concentration and delayed neurological sequelae incidence.

Enrollment: 96 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age v 18 years
• Carbon monoxide intoxication as major problem leading to emergency department admission
• Carboxyhemoglobin (COHb) concentration 10% at the time of enrolment

Exclusion criteria

• Age < 18 years
• Glasgow coma scale ≤ 13
• Refusal to give consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

96 participants in 2 patient groups

High-flow nasal cannula group

Experimental group

Description:

Patients randomised in this group will receive oxygen therapy via a high-flow nasal cannula device with a 60 L/min flow and a 100% fraction of inspired oxygen

Treatment:

Device: High-flow nasal cannula device

Non-rebreathing oxygen mask group

Other group

Description:

In this group patients will be treated with standard oxygen therapy delivered through a non-rebreathing face mask with a 15 L/min flow

Treatment:

Device: Non-rebreathing oxygen mask group