The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

University Ghent

Status: Enrolling

Conditions: Histamine

Treatments: Drug: Placebo; Behavioral: Resistance training; Drug: H1 blockade: Telfast: 180mg Fexofenadine

Study type: Interventional

Funder types: Other

Identifiers

NCT06152497

MPSH - ONZ-2023-0027

Details and patient eligibility

About

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Enrollment: 50 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• 18-45 years
• Not to medium physically active

Exclusion criteria

• Smoking
• Chronic disease
• High blood pressure
• Supplement or medication intake
• Seasonal allergies
• Vegetarian / vegan
• Resistance trained

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

50 participants in 2 patient groups, including a placebo group

1: Placebo

Placebo Comparator group

Description:

Lactose

Treatment:

Behavioral: Resistance training

Drug: Placebo

H1 blockade: Telfast (180mg Fexofenadine)

Experimental group

Description:

H1: Telfast (180mg Fexofenadine)

Treatment:

Behavioral: Resistance training

Drug: H1 blockade: Telfast: 180mg Fexofenadine