The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects

Danish Headache Center

Status

Completed

Conditions

Headache

Treatments

Other: Ketorolac

Other: Sumatriptan

Study type

Interventional

Funder types

Other

Identifiers

NCT03585894

H-18008313

Details and patient eligibility

About

Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and pre-posttreated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on healthy volunteers.

Full description

The purpose of this research project is to investigate the importance of blood vessel (vasodilatation), vessel wall inflammation and blood flow in arteries of headaches triggered by PACAP38 and for headache treated with sumatriptan (migraine medicine) and ketorolac (NSAID). In addition, we will investigate headache-related changes in the brain's network connectivity.

Enrollment

34 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers
Aged 18-50
50-100 kg

Exclusion criteria

Tension type headache more than 5 dag /month
Other primary headaches
Daily medication except contraceptives
Drug taken within 4 times the half-life for the specific drug except contraceptives
Pregnant or lactating women
Exposure to radiation within the last year
Headache within the last 24 hours before start of trial
Hypertension
Hypotension
Respiratory or cardiac disease
Primary relatives with current or previous migraine