The Role of Lactate in Viral and Bacterial Infection

Army Medical University of People's Liberation Army

Status: Completed

Conditions: Viral Infection; Lactate Blood Increase; Bacterial Infections

Treatments: Other: viral infection; Other: viral and bacterial infection

Study type: Observational

Funder types: Other

Identifiers

NCT04777747

lactate for infection

Details and patient eligibility

About

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.

Full description

Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.

Enrollment: 400 patients

Sex: All

Ages: 1 minute to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• child's age is from 0 to 18 years
• a child is at least diagnosed with viral infection

Exclusion criteria

one of the following conditions appeared:

• congenital heart disease or other abnormalities
• respiratory failure
• hereditary and/or metabolic disease

Trial design

400 participants in 2 patient groups

viral infection

Description:

a child is infected by virus only

Treatment:

Other: viral infection

viral and bacterial infection

Description:

a child is infected by virus and progress to bacterial infection

Treatment:

Other: viral and bacterial infection