The Role of Leptin Receptors in NASH

University of California (UC) Davis

Status: Completed

Conditions: Metabolic Syndrome; Nonalcoholic Steatohepatitis

Treatments: Other: no interventions, only regular blood-draw

Study type: Observational

Funder types: Other

Identifiers

NCT00583999

2000513532

Details and patient eligibility

About

NAFLD is a spectrum of liver diseases associated with varying degrees of hepatic steatosis, inflammation, and in some cases, fibrosis. NAFLD is a common observation in all demographics, but the prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) is especially high in the morbidly obese population. Leptin is a cytokine that is encoded by the ob gene and primarily secreted by adipose tissue. The production of serum leptin increases with progressive obesity. Because of this observation, there has been significant interest in potential role of leptin in NAFLD.

Our hypothesis is that we will find increased hepatic leptin and leptin receptor expression as the degree of hepatic injury worsens in NAFLD.

Enrollment: 104 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients undergoing elective bariatric surgery, ages 18-65.

Exclusion criteria

• non-obese patients, ages less than 18 and over 65. Pregnant patients.

Trial design

104 participants in 1 patient group

A

Description:

bariatric surgery

Treatment:

Other: no interventions, only regular blood-draw