The Role of Long Non-coding RNAs WRAP53 and UCA-1 as Potential Biomarkers in Diagnosis of Hepatocellular Carcinoma

Alexandria University

Status: Unknown

Conditions: Liver Cirrhosis; Hepatocellular Carcinoma; Diagnoses Disease

Treatments: Diagnostic Test: WRAP53, UCA-1

Study type: Observational

Funder types: Other

Identifiers

NCT05088811

HCC medical research institute

Details and patient eligibility

About

The aim of this work is to study the role of long non-coding RNAs WRAP53 and urothelial carcinoma-associated 1 (UCA1) as potential biomarkers in diagnosis of hepatocellular carcinoma.

Full description

Sample size calculation was done in department of medical statistics, Medical Research Institute, Alexandria University and the total minimal sample size was calculated.

A prospective case control study will be conducted on 80 subjects divided into three groups:

Group (1): Thirty patients having liver cirrhosis and hepatocellular carcinoma diagnosed by tripahsic CT.

Group (2): Thirty liver cirrhosis patients without hepatocellular carcinoma diagnosed by abdominal ultrasound examination.

Group (3): Twenty normal subjects (control group) matching in age and sex with patients in groups 1 and 2.

Patients will be recruited from the outpatient clinics and inpatient wards of Alexandria Main University Hospital and Medical Research Institute Hospital. Full informed consent will be taken from the patients and approval of the ethical committee of the Faculty of Medicine will be fulfilled. Exclusion criteria: Patients with any inflammatory diseases or other malignancies.

Enrollment: 80 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Any subject without any of the exclusion criteria

Exclusion criteria

• Patients with any inflammatory diseases or other malignancies.

Trial design

80 participants in 3 patient groups

Liver cirrhosis

Description:

Group (1): Thirty patients having liver cirrhosis and hepatocellular carcinoma diagnosed by tripahsic CT.

Treatment:

Diagnostic Test: WRAP53, UCA-1

Hepatocellular Carcinoma

Description:

Group (2): Thirty liver cirrhosis patients without hepatocellular carcinoma diagnosed by abdominal ultrasound examination

Treatment:

Diagnostic Test: WRAP53, UCA-1

Control

Description:

Group (3): Twenty normal subjects (control group) matching in age and sex with patients in groups 1 and 2.

Treatment:

Diagnostic Test: WRAP53, UCA-1