The Role of Mid-Life Adiposity in Functional Brain Connectivity

Medical College of Wisconsin

Status: Terminated

Conditions: Alzheimer's Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01777789

PRO16109

Details and patient eligibility

About

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Full description

Participants will have one visit for:

Blood draw Body composition scan Cognitive screen Neurological exam MRI scan

The visit will take approximately 3 hours.

Enrollment: 60 patients

Sex: All

Ages: 45 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 45-65 years of age
• Normal memory
• Right-handed
• General good physical health

Exclusion criteria

• History of stroke or neurological disease
• Seizures or head injury with loss of consciousness within the last five years
• Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
• Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.