The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Hangzhou Normal University

Status: Completed

Conditions: Vegetative State; Minimally Conscious State

Treatments: Diagnostic Test: functional magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT03492294

2008W1224

Details and patient eligibility

About

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Full description

Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music.

Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Enrollment: 11 patients

Sex: All

Ages: 21 to 61 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 years old;
• no administration of neuromuscular blockers or sedation within the 24 hours of enrolment;
• brain damage with eye opening (indicating wakefulness and rest cycles)

Exclusion criteria

• Coma;
• neurodegenerative disease;
• psychiatric or neurologic illness;
• with intracranial metal or other body metal.

Trial design

11 participants in 1 patient group

patients with disorders of consciousness

Description:

patients with disorders of consciousness from several brain injury have been clinically classified into coma, unresponsive wakefulness syndrome and minimally conscious state. These patients were scaned by functional magnetic resonance imaging.

Treatment:

Diagnostic Test: functional magnetic resonance imaging