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The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

H

Hangzhou Normal University

Status

Completed

Conditions

Vegetative State
Minimally Conscious State

Treatments

Diagnostic Test: functional magnetic resonance imaging

Study type

Observational

Funder types

Other

Identifiers

NCT03492294
2008W1224

Details and patient eligibility

About

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Full description

Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music.

Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Enrollment

11 patients

Sex

All

Ages

21 to 61 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age ≥ 18 years old;
  • no administration of neuromuscular blockers or sedation within the 24 hours of enrolment;
  • brain damage with eye opening (indicating wakefulness and rest cycles)

Exclusion criteria

  • Coma;
  • neurodegenerative disease;
  • psychiatric or neurologic illness;
  • with intracranial metal or other body metal.

Trial design

11 participants in 1 patient group

patients with disorders of consciousness
Description:
patients with disorders of consciousness from several brain injury have been clinically classified into coma, unresponsive wakefulness syndrome and minimally conscious state. These patients were scaned by functional magnetic resonance imaging.
Treatment:
Diagnostic Test: functional magnetic resonance imaging

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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