The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis

Charles University, Czech Republic

Status: Completed

Conditions: Sepsis Syndrome; Systemic Inflammatory Response Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT03314831

ACMYR-001

Details and patient eligibility

About

The aim of the study is to measure serum levels of myristic acid in septic patients and to compare them with myristic acid serum levels in patients with Systemic Inflammatory Response Syndrome of non infective etiology and in healthy volunteers. Furthermore, other biomarkers of sepsis are evaluated in comparison with microbiological findings detected either by standard hemocultures or by molecular biological methods.

Full description

Currently, there is an array of biomarkers potentially useful in diagnosis and prognosis in septic patients, either alone or in combination. Only a fraction of them is used in clinical practice. The reasons vary, low sensitivity or specificity is the main one, cost/benefit or difficult processing with the need of highly specialized laboratory to name the other.

Recent pilot study from Swedish authors (A.M.Kauppi et al.) published in 2016 showed high correlation of myristic acid levels in blood in patients with sepsis and bacteraemia. There was no other publication on this molecule in relation to sepsis before. Cambiaghi et al. observed its significant decrease in nonresponders to the treatment of septic shock.

Myristic acid is an organic acid of linear structure. Measurement of its level will be performed using gas chromatography linked with mass spectrometry.

Enrollment: 282 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sepsis or septic shock.
• Systemic inflammatory response syndrome.
• Subjects without systemic inflammation.

Exclusion criteria

• There is no exclusion criteria in the study

Trial design

282 participants in 3 patient groups

Sepsis

Description:

Patients with sepsis or septic shock admitted on Intensive Care Unit.

Systemic Inflammatory Response Syndrome

Description:

Patients with Systemic Inflammatory Response Syndrome non-infectious etiology.

No inflammation

Description:

Patients without systemic inflammation.