The Role of Narrowband Ultraviolet B Exposure in the Maintenance of Vitamin D Levels During Winter

Joint Authority for Päijät-Häme Social and Health Care

Status: Completed

Conditions: Vitamin D Deficiency

Treatments: Radiation: nbUVB

Study type: Interventional

Funder types: Other

Identifiers

NCT02275650

maintenance_uv

Details and patient eligibility

About

The investigators investigated the ability of narrowband ultraviolet B (nbUVB) treatment in the maintenance of vitamin D levels achieved during the summer in Finland. The investigators randomized 37 subjects into groups of 17 and 18 subjects. The other group received 2 standard erythema doses (SED) nbUVB exposure every other week until week 24, and serum 25(OH)D levels were measured at the onset and at weeks 6, 14, 20, 26 and 30. The control group was not illuminated and serum samples were analyzed correspondingly. Punch biopsies were taken at the onset and at week 14 for CYP27A1 and CYP27B1 enzyme expression level analyses.

Full description

The investigators investigated the ability of narrowband ultraviolet B (nbUVB) treatment in the maintenance of vitamin D levels achieved during the summer in Finland. The investigators randomized 37 subjects into groups of 17 and 18 subjects. The other group received 2 standard erythema doses (SED) nbUVB exposure every other week until week 24, and serum 25(OH)D levels were measured at the onset and at weeks 6, 14, 20, 26 and 30. The control group was not illuminated and serum samples were analyzed correspondingly. 6mm punch biopsies were taken at the onset and at week 14 for CYP27A1 and CYP27B1 enzyme expression level analyses.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age over 18
• Fitzpacker's skin type II-IV

Exclusion criteria

• age under 18
• diseases that inhibit vitamin D metabolism or absorption
• Fitzpacker's skin type I
• history of skin cancer
• vitamin D substitution 1 month before baseline or during study
• sun holidays 1 month before baseline or during study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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37 participants in 2 patient groups

nbUVB

Experimental group

Description:

2 SED dose of nbUVB will be given every other week for this intervention group.

Treatment:

Radiation: nbUVB

control

No Intervention group

Description:

No nbUVB illumination will be given for the control group.