The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study (TONIC)

Universitair Ziekenhuis Brussel

Status: Enrolling

Conditions: Peripheral Blood Mononuclear Cells; Complement Abnormality; Covid19

Treatments: Other: Blood analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05258643

2020/177

Details and patient eligibility

About

The current study is an open, non-randomized, monocentric, and interventional study. CoViD-19 patients will be recruited at UZ Brussel after informed consent is obtained. Whole blood and serum samples will be collected during acute disease (inclusion and 7 days after inclusion) and during patient follow-up at 2 months after infection.

Sample storage and subsequent use in fundamental research will be performed at VUB Neuro-Aging and Viro-Immunotherapy.

Additionally, medical records of UZ Brussel will be searched and epidemiological, clinical, radiological, and biological data of the selected patients will be obtained at the diagnosis time point and during follow-up.

Healthy volunteers will be recruited as well in the current study, as a comparison arm, after informed consent is obtained.

Enrollment: 150 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Covid-19 patients

Inclusion Criteria:

• Positive nasopharyngeal reverse transcriptase-polymerase chain reaction for SARS-Coronavirus-02
• Signed inform consent

Healthy Volunteers

Inclusion Criteria:

• Signed inform consent

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 2 patient groups

Covid-19 patients

Other group

Description:

Whole blood and serum samples will be collected during acute disease (inclusion and 7 days after inclusion) and during patient follow-up at 2 months after infection

Treatment:

Other: Blood analysis

Controle

Other group

Description:

Whole blood and serum samples will be collected during the same period

Treatment:

Other: Blood analysis