The Role of Netrin -1 in Acute Coronary Syndrome (ACS-NETRİN-1)

Aksaray University Training and Research Hospital

Status: Completed

Conditions: Acute Coronary Syndrome

Treatments: Other: netrin-1 value on admission to hospital

Study type: Interventional

Funder types: Other

Identifiers

NCT04027127

aksaray 2013-23

Details and patient eligibility

About

In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher Netrin-1 levels.

Enrollment: 238 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over the age of 18
• diagnose ACS
• patients undergoing angiography

Exclusion criteria

• CVE history
• Neurological disease
• Pregnancy and Lactation
• Liver failure
• Diagnosed malignity
• Use of anticonvulsant and nephrotoxic medication
• Chronic kidney disease
• Not having angiography
• Developing acute renal failure after angiography
• Patients who rejected to participate were excluded.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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238 participants in 2 patient groups

ACS GRUP

Active Comparator group

Description:

Demographic characteristics, history, vital signs, laboratory findings, coronary angiography (CAG) and echocardiography (ECO) findings of the patients were recorded. Netrin-1 levels were studied with blood collected at the hospital and 6-8 hours after CAG. CAG results were evaluated by TIMI flow. The patients were divided into two groups with and without TIMI 3 flow and Netrin-1 levels were compared. GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Ischemia) clinical risk assessments were performed and Netrin-1 values were compared.

Treatment:

Other: netrin-1 value on admission to hospital

plasebo grup

Active Comparator group

Description:

It consisted of those without any disease and netri-1 values at admission were compared with the uptake patient group.

Treatment:

Other: netrin-1 value on admission to hospital