The Role of Novel Organisms in Acute Endometritis

Sharon Hillier

Status: Completed

Conditions: Pelvic Inflammatory Disease

Treatments: Other: no intervention

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01236131

PRO10080491

1U19AI084024-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this project is to identify the microorganisms present in the endometrial samples obtained from women with or without evidence of endometritis using a combination of culture methods, rRNA sequencing and whole genomic sequencing. The overarching aim of these studies is to identify the etiology of endometritis. The investigators will define the role of fastidious anaerobic microorganisms in the etiology of PID, and assess whether antibiotic treatment regimens used for the treatment of PID have activity against the novel organisms linked with pelvic infections.

Enrollment: 480 patients

Sex: Female

Ages: 15 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• This is a laboratory research study involving the use of biologic specimens only.
• Specimens (endometrial biopsy samples) collected from subjects who meet the inclusion criteria for PRO10010159 and PRO10010112 will be utilized for this study.

Exclusion criteria

• Specimens (endometrial biopsy samples) that are collected from subjects enrolled in PRO10010159 and PRO10010112 that are insufficient will not be included in this study.

Trial design

480 participants in 1 patient group

Endometrial biospy samples

Description:

The Endometrial Biopsy samples will be provided by women enrolled in the University of Pittsburgh IRB PRO10010112 and PRO10010159

Treatment:

Other: no intervention