The Role of OCTA in Patients Affected by Beta Thalassemia

Federico II University

Status

Completed

Conditions

Thalassemia

Treatments

Diagnostic Test: Optical coherence tomography angiography

Study type

Observational

Funder types

Other

Identifiers

NCT04582110

1002/19

Details and patient eligibility

About

To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia. Moreover we analyzed the structural retinal parameters (ganglion cell complex and retinal nerve fiber layer), using optical coherence tomography (OCT) in these patients

Full description

Beta Thalassemia is one of the most common genetic hemoglobinopathy characterized by a defective β globulin chain synthesis leading to hemolysis and ineffective erythropoiesis.

The study investigated the changes in retinal and choriocapillaris vascular features using optical coherence tomography angiography, a novel and noninvasive diagnostic technique that allows a detailed analysis of retinal and choriocapillaris blood flow.

Enrollment

82 patients

Sex

All

Ages

35 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

age older than 35 years
diagnosis of Beta Thalassemia
absence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
absence of significant lens opacities, low-quality OCT and OCT-A images.

Exclusion criteria

age older than 50 years
absence of diagnosis of Beta Thalassemia
presence of previous ocular surgery, congenital eye disease, high myopia (>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
presence of significant lens opacities, low-quality OCT and OCT-A images.