The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.

University of Copenhagen

Status

Completed

Conditions

Obesity

Treatments

Drug: Peptide YY infusion

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00259246

B208,1

Details and patient eligibility

About

The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake and energy expenditure.

Full description

The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are served in the hours following the infusion. Energy expenditure is measured by ventilated hood system and blood is sampled during part of the study day.

Sex

Male

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Normal weight (BMI: 18-23 kg/m2) or 12 overweight/obese (BMI: 27-40 kg/m2)
Body weight fluctuations < 5 kg over the past 2 months.
Blood pressure normal to mildly hypertensive (<159/99 mm Hg)
Non-elite athletes and not planning to change physical activity during the study.

Exclusion criteria

Any physiological or psychological illnesses that could influence the study results
Regular use of medicine
Smoking defined as <1 cigarette per day.
Substance abuse or dependence.
Blood donation within the past 3 months before entering the study
Drinking >21 alcoholic units/week.
Food allergies.
Special diets (e.g. vegetarian) or dislikes to any of the foods served during the study.