The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke

Pomeranian Medical University Szczecin

Status: Completed

Conditions: Stroke; Periodontal Diseases; Saliva Altered

Treatments: Diagnostic Test: saliva stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05394090

Pomeranian Medical University

Details and patient eligibility

About

Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated. The severity of the neurological condition was assessed using the NIHSS scale on days 1, 3 and 7 of stroke. The incidence of periodontal diseases was classified using the Hall's scale in the 1st day of stroke. On days 1 and 7 of stroke, the concentration of IL-1beta, MMP8, OPG and RANKL in the patients' saliva was assessed using the Elisa technique. At the same time, the level of CRP and the number of leukocytes in the peripheral blood were tested on days 1, 3 and 7 of the stroke, and the incidence of upper respiratory and urinary tract infections was assessed.

Full description

The course of an ischemic stroke varies by many factors. The influence of periodontal diseases and the stimulation of salivation on the course and difficulty of stroke remains unresolved.

Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated. The severity of the neurological condition was assessed using the NIHSS scale on days 1, 3 and 7 of stroke. The incidence of periodontal diseases was classified using the Hall's scale in the 1st day of stroke. On days 1 and 7 of stroke, the concentration of IL-1beta, MMP8, OPG and RANKL in the patients' saliva was assessed using the Elisa technique. At the same time, the level of CRP and the number of leukocytes in the peripheral blood were tested on days 1, 3 and 7 of the stroke, and the incidence of upper respiratory and urinary tract infections was assessed.

Enrollment: 50 patients

Sex: All

Ages: 48 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men and women,
• at the age of 48-80,
• first-ever stroke,
• with symptoms from the anterior cerebral vascularity (basin of the internal carotid artery),
• with a significant neurological deficit (minimum 3 points according to the NIH scale)
• capable of giving informed consent;

Exclusion criteria

• aphasia, disturbance of consciousness, mental disorders - making it impossible to express informed consent
• surgery of the salivary glands - disrupting the secretion of saliva
• diseases of the salivary glands that disrupt the secretion of saliva (diabetes, Sjögren's syndrome, state after radiotherapy in the area of the salivary glands)

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

saliva-stimulated group

Experimental group

Description:

In approximately 50 randomly selected patients (group 1), from the second day of admission until the end of hospitalization, a 15-minute manual stimulation of the submandibular and sublingual bib was performed internally and externally. In addition, oral hygiene was performed in patients, taking into account the tongue and cheeks.

Treatment:

Diagnostic Test: saliva stimulation

the group in which the saliva was not stimulated

No Intervention group

Description:

There was no saliva in the group of 50 patients