The Role of Perirenal Fat As Predictor in Diabetic Nephropathy

Assiut University

Status: Not yet enrolling

Conditions: Diabetic

Treatments: Device: Sonar

Study type: Observational

Funder types: Other

Identifiers

NCT06815224

Perirenal fat in diabetic

Details and patient eligibility

About

1 detect the relationship between perirenal fat thickness (PrFT) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes (T2DM).

2)Explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes 3)Evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in patients with type 2 diabetes mellitus (DM)

Full description

Diabetic kidney disease (DKD) is the most frequent and severe complication of diabetes mellitus (DM). Approximately 40% of patients with diabetes present with proteinuria and renal dysfunction and DKD reportedly account for 50% of newly diagnosed end-stage renal disease (ESRD) . Metabolic disorders caused by hyperglycemia in DKD can lead to both glucose and lipid metabolism disorders. Not only hyperglycemia, many factors including obesity have been reported to be risk factors for diabetic kidney disease .

Body mass index (BMI) and waist circumference (WC), widely used as obesity indexes, have been proved to aggravate the development of CKD in different subsets of patients , but BMI and WC lack detailed information about the distribution of body fat. Body fat is now usually divided into subcutaneous fat and visceral fat according to the anatomical and physiological functions of fat deposition . Visceral fat has been thought to be associated with the progression of CKD .

Recently, new anthropometric and imaging methods have been used to assess visceral fat in clinical practice and research. Perirenal fat is a fat pad surrounding the kidneys, located between the renal fibrous membrane and the renal fascia in the retroperitoneal space .PRF has been reported to be associated with renal disease in various ways.Additionally, it has been proved that renal sinus fat was associated with an increased risk of CKD in general subjects through inflammatory signaling

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with T2DM aged 18-70 were included in this study. T2DM was diagnosed according to American Diabetes Association (ADA) ,Data collection will obtained over one year from October 2024 to October 2025.

Clinical diagnosis of Alzheimer's Disease Must be able to swallow tablets

Exclusion criteria

• b. Exclusion criteria:

  1. patients with a history of malignancy and surgical trauma.
  2. patients diagnosed with nondiabetic renal diseases
  3. Patients with renal replacement therapy (renal transplant or dialysis patients), renal morphological abnormalities (difference in kidney length between the two cm, solitary kidney or multiple kidneys, congenital kidney abnormalities, polycystic kidney, and hydronephrosis), liver cirrhosis.
  4. Insulin dependent diabetes
  5. Thyroid disease