The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory

Taipei Veterans General Hospital

Status: Unknown

Conditions: Central Nervous System Diseases

Treatments: Device: Functional near infrared spectroscopy; Device: rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT02006615

2013-07-011A

Details and patient eligibility

About

The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Full description

Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.

Enrollment: 150 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Ischemic or hemorrhagic cerebrovascular lesion,
2. Parkinson's disease

Exclusion criteria

• Seizure
• With metal implantation
• Dementia or severe cognitive impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 3 patient groups

High frequency rTMS plus fNIRS

Experimental group

Description:

rTMS with neuroimage assessment of functional near infrared spectroscopy

Treatment:

Device: rTMS

Device: Functional near infrared spectroscopy

Sham rTMS

Sham Comparator group

Description:

Sham stimulation

Treatment:

Device: rTMS

High frequency rTMS

Experimental group

Description:

High frequency rTMS to modulate brain areas

Treatment:

Device: rTMS