The Role of Progesterone and PIF for Successful Implantation and On-going Pregnancy in Assisted Reproductive Technology

Regionshospitalet Viborg, Skive

Status: Completed

Conditions: Infertility

Treatments: Other: IVF/ICSI treatment

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02129998

Progesterone/PIF_Skive

Details and patient eligibility

About

The aim of this study is to achieve a more profound understanding of the endocrine alteration in luteal progesterone level after gonadotrophin stimulated IVF/ICSI cycles and to explore the optimal progesterone level needed for securing implantation and development of early pregnancy.

The second part of the project will determine the value of Preimplantation Factor (PIF) measurement in embryo culture medium as a possible tool for improved embryo selection and the use of PIF as an early pregnancy serum marker for healthy implantation and embryo development.

IVF: In vitro fertilisation, ICSI: Intracytoplasmic sperm injection.

Enrollment: 873 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-All women undergoing IVF/ICSI treatment at the participating clinics in either antagonist protocol or long agonist protocol will be offered participation.

Exclusion criteria

-Prior participation in the study

Trial design

873 participants in 1 patient group

Standard IVF/ICSI treatment

Treatment:

Other: IVF/ICSI treatment