The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Uniwersytet Mikolaja Kopernika w Toruniu

Status

Unknown

Conditions

Kidney Transplantation

Treatments

Behavioral: Oxidative stress in kidney transplant recipients

Study type

Observational

Funder types

Other

Identifiers

NCT00204178

KB/38/2003

Details and patient eligibility

About

Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

Full description

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria