The Role of Serum Anticholinergic Activity in ACVB Patients

Heidelberg University

Status: Completed

Conditions: BIS-EEG; Acetylcholine; Cognition

Study type: Observational

Funder types: Other

Identifiers

NCT00782938

S235-2008

Details and patient eligibility

About

Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.

Enrollment: 100 estimated patients

Sex: All

Ages: 55 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• written compliance to the study participation
• a good knowledge in German speech
• no red/ green blindness
• no previous neurological and/or psychiatric illness
• good ability to see and to hear
• Mini-Mental-State-Examination (MMSE) better than 25 points

Exclusion criteria

• no written compliance to the study participation
• bad knowledge in German speech
• red/ green blindness
• previous neurological and/or psychiatric illness
• no ability to see and to hear
• Mini-Mental-State-Examination (MMSE) lower than 25 points

Trial design

100 participants in 2 patient groups

low SAA

high SAA