The Role of Smoking and Gingival Crevicular Fluid Markers on Coronally Advanced Flap Outcomes

Ege University

Status: Completed

Conditions: Gingival Recession; Smoking

Treatments: Procedure: Coronally Advanced Flap

Study type: Interventional

Funder types: Other

Identifiers

NCT03539939

2010-DIS-004

Details and patient eligibility

About

Cigarette smoking is a patient-related factor that can affect healing of periodontal tissues and the success rate of root-coverage procedures. Neither the nature nor the mechanisms of action of cigarette smoking on root coverage are fully understood. Therefore, the hypothesis that cigarette smoking has negative impacts on the outcomes of root coverage after CAF surgery in systemically healthy individuals with an initial gingival thickness of at least 0.8 mm and who practice optimal oral hygiene was tested. It was also hypothesized that baseline analysis of disease-related biomarkers would shed light on the underlying mechanisms of a possible effect.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Maxillary central and lateral incisors, canines, and premolars and mandibular premolars with isolated buccal recessions classified as Miller Class I or II
• Study tooth should present tooth vitality, identifiable cemento-enamel junction (CEJ) and absence of caries, restorations or extensive non-carious cervical lesion.

Exclusion criteria

• Medical disorders such as diabetes mellitus, immunologic disorders, hepatitis
• History of previous mucogingival surgery at the gingival recession site
• Medications known to affect gingival tissues
• Antibiotic treatment in the past 6 months
• Pregnancy or lactation

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Smoker Group

Experimental group

Description:

This group included smoker gingival recession patients.

Treatment:

Procedure: Coronally Advanced Flap

Non-smoker Group

Active Comparator group

Description:

This group included non-smoker gingival recession patients.

Treatment:

Procedure: Coronally Advanced Flap