The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage

University of Sao Paulo General Hospital

Status and phase: Unknown; Phase 4

Conditions: Aneurysmal Subarachnoid Hemorrhage

Treatments: Drug: statin

Study type: Interventional

Funder types: Other

Identifiers

NCT01346748

1268/09

Details and patient eligibility

About

Delayed ischemia caused by cerebral vasospasm remains a common cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. A great deal of drugs has been tested in the last years. Phase II randomized clinical trials have demonstrated that statin decreases the incidence of symptomatic cerebral vasospasm after spontaneous subarachnoid hemorrhage. Clinical, double blind, randomized controlled trials with placebo. Discussion: Even though some articles have shown that statins provide better prognosis, some issues remain in debate, e.g., treatment duration and the choice of the statin.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 65 years old, Hunt-hess scale < 3

Exclusion criteria

• Liver disfunction, previous use of statin, hunt-hess scale 4 or 5.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 1 patient group

Statin

Experimental group

Treatment:

Drug: statin