The Role of the Coagulation Pathways in Recurrent Angioedema (Angiocoag)

University Hospital Center (CHU)

Status: Terminated

Conditions: Chronic Spotaneous Urticaria, Idiopathic Non Histaminergic Angioderma, Hereditary Angioedema With C1 Inhibitor Deficiency

Treatments: Other: BLOOD TEST

Study type: Interventional

Funder types: Other

Identifiers

NCT02892682

UF 9650

Details and patient eligibility

About

Previous studies reported infraclinical modifications of the homeostasis in chronic urticaria, recurrent idiopathic angioedema and hereditary angioedema. This study aim to compare groups with isolated wheals, isolated angioedema, combination of both and hereditary angioedema in terms of coagulation pathways.

Full description

Previous studies reported infraclinical modifications of the homeostasis in chronic urticaria, recurrent idiopathic angioedema and hereditary angioedema. This study aim to compare groups with isolated wheals, isolated angioedema, combination of both and hereditary angioedema in terms of coagulation pathways. the main objective is to highlight a difference between the rates of different coagulation factors in the 3 groups presenting different categories of angiodemes patients with a group of patients with isolated superficial chronic urticaria

Enrollment: 96 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• recurrent angioderma

Exclusion criteria

• anticoagulant therapy, diseases of hemostasis

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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96 participants in 4 patient groups

Arm 1 AE-Bk

Other group

Description:

Arm of the recurring angiodeme medié by the bradykinine: blood test

Treatment:

Other: BLOOD TEST

Arm 2 AE-Mast

Other group

Description:

Superficial nettle rash group recurring angiodemes associated with superficial nettle rash: blood test

Treatment:

Other: BLOOD TEST

ARM 3 AEI

Other group

Description:

Arm recurring angiodemes isolate idiopathique not hostaminergique: blood test

Treatment:

Other: BLOOD TEST

ARM 4 US

Other group

Description:

Arm of superficial nettle rashes: blood test

Treatment:

Other: BLOOD TEST