The Role of the Upper Colliculus in the Idiopathic Blepharospasm (COLL-BSP)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Blepharospasm, Benign Essential

Treatments: Other: fMRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03903341

38RC17.399

Details and patient eligibility

About

This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.

Full description

The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).

Enrollment: 13 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non treated idiopathic blepharospasm
• Age: 30- 70 years

Exclusion criteria

• Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium
• No MRI Contraindication

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

13 participants in 2 patient groups

idiopathic blepharospasm (BSP) de novo

Other group

Description:

bold signal in visual pathway

Treatment:

Other: fMRI

Healthy subjects

Other group

Description:

bold signal in visual pathway

Treatment:

Other: fMRI