The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency

Tarik Emre Sener

Status: Not yet enrolling

Conditions: Vitamin D Deficiency; Overactive Bladder

Treatments: Behavioral: Urotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT07513363

MAR.UAD.0031

Details and patient eligibility

About

The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of children aged 4-18 diagnosed with Overactive Bladder (OAB) and Vitamin D deficiency.

Enrollment: 52 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children aged 4-18 years presenting with active OAB symptoms (frequency, urgency)

Exclusion criteria

• Neurological diseases
• Malignancy
• Active urinary tract infections
• Anatomical bladder anomalies
• History of prior OAB treatment/urological surgery.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups

Overactive Bladder Group

Active Comparator group

Treatment:

Behavioral: Urotherapy

Healthy Group

No Intervention group