The Role of Whey and Lupin in Glycemic Control (Nutritional Pre-Study) (NPS)

German Aerospace Center (DLR)

Status: Completed

Conditions: Whole Body Glucose and Insulin Metabolism

Treatments: Other: Reference; Dietary Supplement: Whey Protein; Dietary Supplement: Lupin Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT02413671

NPS

Details and patient eligibility

About

The study compared the acute effects of the supplementation of a standardized meal with either lupin or whey protein or no protein on the whole-body glucose and insuline metabolism.

Full description

The nutritional pre-study had the following key objectives:

Primary objective:

• Lupin protein lowers the postprandial blood glucose level equivalent to or to a greater extent than whey protein.

Secondary objective:

• Lupin protein has an equivalent or a stronger insulinotropic effect than whey protein.

Enrollment: 12 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female and male volunteers
• Age: between 20 and 45 years
• Body mass index (BMI): 20-28 kg/m²
• Fasting blood glucose within normal ranges (70-99 mg/dl; 29-42 mmol/mol Hb)
• Glycated hemoglobin HbA1c within normal ranges (4-6%)
• Agreement and signed informed consent before the study

Exclusion criteria

• Diabetes mellitus
• Increased bleeding tendency (hemophilia, regular use of anticoagulants)
• Allergy to nuts, legume or milk protein
• Drug, medication or alcohol abuse (frequent consumption of more than 20-30g alcohol/day)
• Intake of medication during the study
• Smoker
• Competitive athletes
• Extreme eating habits (vegan, special diets)
• Any other condition classed as unsuitable by the executive medical director

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 3 patient groups

Lupin Protein

Other group

Description:

Subjects received a test meal rich in carbohydrates and supplemented with lupin protein.

Treatment:

Dietary Supplement: Lupin Protein

Whey Protein

Other group

Description:

Subjects received a test meal rich in carbohydrates and supplemented with whey protein.

Treatment:

Dietary Supplement: Whey Protein

Reference

Other group

Description:

Subjects received a test meal rich in carbohydrates not supplemented with any protein.

Treatment:

Other: Reference