The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis

Nanjing Medical University

Status: Enrolling

Conditions: Intestinal Mucosal Barrier; Ferroptosis; Sepsis

Treatments: Procedure: Standard treatments for sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT05410665

YKK21134

Details and patient eligibility

About

The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Clinical diagnosis of sepsis
2. Within 3 days of sepsis onset before ICU admission
3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission

Exclusion criteria

1. Ileus
2. Digestive tract hemorrhage
3. Inflammatory bowel disease
4. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction)
5. Malnutrition or immunodeficiency
6. Long-term use of hormones

Trial design

100 participants in 2 patient groups

Sepsis group

Description:

Adult septic patients admitted into the intensive care unit (ICU) of Nanjing First Hospital. The diagnostic criteria for sepsis were in accordance with the surviving sepsis guidelines.

Treatment:

Procedure: Standard treatments for sepsis

Control group

Description:

Baseline data (including age, sex, body-mass index, disease severity scores) matched adult non-septic critical patients in our ICU.