The Rule of Bupivacaine Hydrochloride in Skin Graft Donor Site

Minia University

Status and phase: Completed; Phase 2

Conditions: Pain Management; Skin Graft Complications

Treatments: Drug: Bupivacain

Study type: Interventional

Funder types: Other

Identifiers

NCT06766474

bupivacaine analgesia

Details and patient eligibility

About

Split Thickness Skin Graft is frequently utilized for reconstructing skin loss of various causes. Unfortunately, the donor site of the STSG has an unavoidable, annoying post-operative pain

Full description

The primary objective of this study was to compare the efficacy of bupivacaine hydrochloride-soaked dressing versus bupivacaine HCL subcutaneous infiltration for postoperative donor site pain control for patients undergoing STSG procedures. The patients were divided in 3 equal groups, investigated soaked dressing vs subcutaneous infiltration vs conventional dressing .

Enrollment: 90 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists Physical Status classification I-II
• scheduled for STSG harvested from a single thigh donor site to reconstruct skin loss post burn or trauma

Exclusion criteria

• uncooperative
• refusing patient,
• under immunosuppressive treatment
• diabetics
• lower-limb neuropathy
• under corticosteroids treatment
• allergy to the study drug,
• STSG procedures performed under spinal anesthesia
• pregnancy
• had a history of opioid abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

90 participants in 3 patient groups

Group I (soaked dressing group)

Experimental group

Description:

the donor site dressing was kept soaked in an aqueous solution of bupivacaine HCL in a concentration of 0.25%.

Treatment:

Drug: Bupivacain

Group II (subcutaneous infiltration group)

Experimental group

Description:

Subcutaneous infiltration of the study medication.

Treatment:

Drug: Bupivacain

Group III (control group)

No Intervention group

Description:

the conventional dressing was applied without any adjectives