The Safe Effective Light Dose of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Yeungnam University College of Medicine

Status: Unknown

Conditions: Central Serous Chorioretinopathy

Treatments: Procedure: Photodynamic therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01630863

YUH-12-007-D4

Details and patient eligibility

About

To find the safe effective lowest light dose for photodynamic therapy (PDT). in the treatment of central serous chorioretinopathy.

Enrollment: 45 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA
2. Presence of SRF and/or serous pigment epithelial detachment on optical coherence tomography (OCT)
3. Presence of abnormal dilated choroidal vasculature in ICGA
4. Patients with symptomatic CSC of at least 3 months duration

Exclusion criteria

1. Patients who received any previous treatment, including PDT or focal thermal laser photocoagulation for CSC, or who had evidence of CNV, PCV, or other maculopathy on clinical examination, FA, or ICGA
2. Patients receiving exogenous corticosteroid treatment
3. Patients with systemic diseases such as Cushing's disease or renal diseases
4. Pregnant patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

50% group

Experimental group

Description:

power of PDT is applied to the patients at 50% of the full energy based on TAP study.

Treatment:

Procedure: Photodynamic therapy

40% group

Experimental group

Description:

Decreasing power of PDT is applied to the patients at 40% of the full energy based on TAP study.

Treatment:

Procedure: Photodynamic therapy

30% group

Experimental group

Description:

Decreasing power of PDT is applied to the patients at 30% of the full energy based on TAP study.

Treatment:

Procedure: Photodynamic therapy