The Safety and Efficacy Evaluation of Echocardiography-guided Percutaneous Radiofrequency Ablation for Cardiac Tumors: a Single-arm, Prospective, Single-center Clinical Study

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Heart Neoplasms

Treatments: Procedure: Echocardiography-guided percutaneous radiofrequency ablation for cardiac tumors

Study type: Interventional

Funder types: Other

Identifiers

NCT06830512

KY20232307-F-2

Details and patient eligibility

About

The safety and efficacy evaluation of echocardiography-guided percutaneous radiofrequency ablation (Liwen prcocedure) for cardiac tumors: a single-arm, prospective, single-center clinical study.

Full description

Cardiac tumor is a rare disease in clinical practice, which is divided into primary cardiac tumor and secondary cardiac tumor, of which secondary cardiac tumor is about 20 to 40 times of primary.The clinical symptoms of cardiac tumors are complex and varied, mainly related to the size and location of tumors. Tumors often lead to blood flow obstruction, arrhythmia, systemic embolism, which seriously threaten the life of patients.At present, surgical resection is the only operation treatment. However, many cardiac tumors have lost the chance of surgery because of many reasons.

Based on previous work, we found echocardiography-guided percutaneous radiofrequency ablation (Liwen procedure) to treat cardiac tumors.This is a single-arm, prospective, single-center clinical study. After signing the informed consent letter, the patients were screened to meet the enrollment conditions and were treated with Liwen procedure for cardiac tumors. Follow-up was performed at 7 days, 30 days, 3 months, 6 months and 12 months.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Hemodynamic changes caused by cardiac tumors or patients with obvious clinical symptoms such as chest tightness, shortness of breath, palpitations, etc., or the risk of embolization of intracardial tumors;
2. Patients who cannot be completely excised by surgery, cannot tolerate surgery or refuse surgery;
3. The patient was informed of the nature of the clinical study and agreed to participate in all the requirements of the clinical study, signed the informed consent, and agreed to complete the follow-up and follow-up examination required.

Exclusion criteria

1. Previously documented persistent ventricular tachycardia or ventricular fibrillation, supraventricular tachycardia with hemodynamic disturbance, cardiac arrest, and high atrioventricular block;
2. Previous history of tumor or thromboembolism exfoliating organ embolism;
3. Combined with other heart diseases requiring surgical treatment;
4. Active infections should be treated with antibiotics;
5. Bleeding constitution and coagulation disorders, or anticoagulation, antiplatelet therapy contraindications;
6. Patients who are pregnant, breastfeeding or planning to become pregnant during the clinical study;
7. The disease will cause difficulties in the evaluation of treatment, such as mental illness, metabolic disease, etc.;
8. Patients who cannot tolerate general anesthesia;
9. Severe liver, kidney, lung, brain and other major organ failure;
10. There are no patients who are suitable for the injection path of Liwen operation;
11. Other diseases deemed unsuitable for inclusion by the researchers;
12. The researcher judged that the patients' dependence was poor and could not complete the study.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

treatment group

Experimental group

Description:

Echocardiography-guided percutaneous radiofrequency ablation

Treatment:

Procedure: Echocardiography-guided percutaneous radiofrequency ablation for cardiac tumors