The Safety and Efficacy of HAIC+Tislelizumab+Regorafenib in Patients With Colorectal Liver Metastases

Peking University Cancer Hospital & Institute

Status and phase

Enrolling

Phase 2

Conditions

Colorectal Liver Metastases

Treatments

Drug: Tislelizumab

Other: HAIC

Drug: Regorafenib

Study type

Interventional

Funder types

Other

Identifiers

NCT05877001

2022KT98

Details and patient eligibility

About

Tislelizumab is an anti-PD-1 monoclonal antibody with high binding affinity for PD-1 and with minimized Fcγ receptor binding on macrophages. Regorafenib has been approved in mCRC by CFDA. Hepatic arterial infusion chemotherapy has a high local control rate for liver metastases. NCCN guidelines and several expert consensus recommend that regional hepatic arterial infusion chemotherapy can be considered as a "rescue treatment" for patients with colorectal cancer liver metastases who fail to receive first-line or second-line systemic chemotherapy, which can significantly prolong the overall survival of patients.

Full description

The investigators aimed to evaluated the safety and efficacy of HAIC combined with Tislelizumab and Regorafenib in patients with advanced treated colorectal liver metastases. This study is a prospective, open label, single-center clinical study and the sample size is 20.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age≥18 years old
Histologically or cytologically confirmed colorectal cancer with unresectable or surgical contraindicated liver metastases
- Extrahepatic metastases are allowed and the primary tumor load is assessed to be intrahepatic by two or more attending physicians
- Whether liver metastases can be resected or not is determined by two or more attending physicians according to the Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases
Patients with unresectable colorectal liver metastases after failed standard second-line therapy
- Including, but not limited to, Oxaliplatin, Fluorouracil, and Irinotecan
- Treatment failure is defined as disease progression and intolerable toxicity
Patients who withdrew from standard therapy due to unacceptable toxicity, guaranteed to discontinue treatment before disease progression and excluded treatment with the same drug, are also allowed to be included in the study.
At least one measurable lesion according to RECIST 1.1 criteria
Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
Subject life expectancy ≥12 weeks
Laboratory tests of bone marrow, hepatic and renal function and coagulation function within 7 days before the first dose of medication meet the study requirements
- No blood transfusion, blood products, or correction with granulocyte colony-stimulating factor or other hematopoietic stimulating factor within 7 days before laboratory testing.
Female patients of childbearing age must have a negative blood pregnancy test within 7 days before the first dose of medication and male or female patients of childbearing age volunteered to take effective contraceptive measures during the whole treatment and within 3 months after treatment
All patients must sign an informed consent form and follow the trial treatment protocol and follow up plan

Exclusion criteria

ANC <1.5×109/L, or platelet count <80×109/L, or HGB < 9g/dL;
- Blood transfusion to meet enrollment criteria within 2 weeks before enrollment is not allowed
serum total bilirubin>2.0 times upper limit of normal
AST and/or ALT>5.0 times upper limit of normal
Serum creatinine>1.5 times upper limit of normal, or creatinine clearance rate<50ml/min(calculated according to the Cockcroft-Gault formula)
APTT or PT>1.5 times upper limit of normal
Clinically significant severe electrolyte abnormalities by the investigator
Urine protein test 2+ or more, or 24 hours urine protein quantitation ≥1.0g/24h
Hypertension that is not stably controlled by medications: systolic blood pressure(SBP) >140mmHg or diastolic blood pressure(DBP) > 90mmHg
Patients with active gastric and duodenal ulcer, ulcerative colitis or other gastrointestinal diseases or unresected tumors with active bleeding, or other conditions that may cause gastrointestinal bleeding or perforation as judged by the investigators; Or patients with previous gastrointestinal perforation or gastrointestinal fistula, which is not cured after surgical treatment
History of arterial or deep-vein thrombosis within 6 months before enrollment or evidence or history of bleeding tendency within 2 months before enrollment, regardless of severity
History of troke or transient ischemic attack within 12 months before enrollment
History of heart disease within 6 months before enrollment, manifested as congestive heart failure, acute myocardial infarction, severe/unstable angina, coronary artery bypass grafting; impaired cardiac function in NYHA class 2 or above; left ventricular ejection fraction (LVEF) <50%
Uncontrolled malignant pleural, ascites, or pericardial effusion
- defined as not being effectively controlled with diuretics or punctures
Clinically detectable second primary malignancy or history of other malignancies within 5 years. Adequately treated nonmelanoma skin cancers, cervical carcinoma in situ, and superficial bladder tumors [noninvasive tumors, carcinoma in situ, and T1 (tumor invasion of the lamina propria)] are excluded
Central nervous system (CNS) metastases or previous brain metastases
Clinically uncontrolled severe active infection
Pregnant or lactating women or women of childbearing age have a positive pregnancy test before the first dose of medication; Or female participants themselves and their partners who are unwilling to use strict contraception during the trial
Patients are considered by the investigator to have any clinical or laboratory abnormalities or compliance issues that precluded participation in the trial
Serious psychological or psychiatric abnormalities