The Safety, Efficacy, and Immune Response of Multimodal Thermal Therapy in the Treatment of Malignant Liver Tumors

Fudan University

Status: Not yet enrolling

Conditions: Colorectal Cancer Liver Metastasis; Hepatocellular Carcinoma

Treatments: Device: Multimodal Tumor Thermal Therapy System; Device: Radiofrequency Ablation System or Microwave Ablation System

Study type: Interventional

Funder types: Other

Identifiers

NCT07159048

2025-308-4457

Details and patient eligibility

About

Multimodal thermal therapy (MTT), as an initiative integration of cryotherapy and radiofrequency heating, has been applied to treat various solid tumors. The feasibility and safety for MTT in the treatment of malignant liver tumors is well-established. This prospective, multi-center, randomized controlled clinical study aimed to explore the ablation-induced immune activating response of MTT in the treatment of malignant liver tumors.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age of 18-75 years.
2. Clinical diagnosis or pathologic of hepatocellular carcinoma (HCC) or metastatic liver cancers.
3. Intrahepatic lesions with a diameter of ≤5cm, and the number of lesions ≤5.
4. Without extrahepatic metastases; for patients with liver metastases, previously underwent radical resection of the primary lesion without local recurrence.
5. Child-Pugh score ≤7 (Class A or B).
6. Performance status 0-1 (Eastern Cooperative Oncology Group classification).
7. Life expectancy of at least 3 months.
8. Patients who have previously undergone surgery, chemotherapy, targeted therapy, ablation, vascular interventional therapy (TACE, D-TACE, HAIC), or immunotherapy, with an interval of ≥3 weeks since the last treatment.
9. The functional level of major organs must meet the following requirements:

(1) Blood Routine: WBC≥3.0×109/L，ANC≥1.5×109/L，PLT≥50×109/L，HGB≥90 g/L. (2) Liver Function: AST ≤5.0×ULN, ALT ≤5.0×ULN, TBIL ≤2.0×ULN. (3) Renal Function: Cr ≤1.5×ULN or CrCl ≥60 mL/min. (4) Coagulation Function: INR ≤1.5; APTT ≤1.5×ULN. (5) HBV-DNA: HBV-DNA ≤2×10³ IU/mL (*Patients with HBV-DNA >2×10³ IU/mL may be enrolled but must receive antiviral therapy.*)

Exclusion criteria

1. Diffuse hepatocellular carcinoma (HCC), or with tumor thrombus in the main portal vein to secondary branches or hepatic veins.
2. Severe liver atrophy or excessively large tumor volume requiring ablation of ≥1/3 of the liver volume.
3. Uncorrectable coagulation dysfunction or severe hematologic abnormalities with a high risk of bleeding.
4. Active bacterial infection or fungal infection.
5. Previous or coexisting malignancies.
6. History of solid organ transplant or hepatic encephalopathy.
7. Current enrollment in another clinical trial or prior exposure to experimental therapies.
8. Pregnant or breastfeeding, or preparing to pregnant.
9. Not suitable to participate in clinical trials judged by investigator.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Multimodal Tumor Thermal Therapy

Experimental group

Description:

These patients will receive multimodal thermal therapy using multimodal tumor thermal therapy system.

Treatment:

Device: Multimodal Tumor Thermal Therapy System

Single Thermal Ablation

Experimental group

Description:

These patients will receive local ablation using the microwave ablation system or radiofrequency ablation system.

Treatment:

Device: Radiofrequency Ablation System or Microwave Ablation System