The Screening and Analysis of Plasma Biomarkers in Irreversible PAH-CHD

Shanghai Jiao Tong University School of Medicine

Status: Completed

Conditions: Hypertension,Pulmonary

Study type: Observational

Funder types: Other

Identifiers

NCT02267200

SCMCIRB-K2014004

Details and patient eligibility

About

The purpose of this study is to analyse the sensitivity and specificity of circulating endothelial cells to predict irreversible pulmonary arterial hypertension associated with congenital heart disease.

Full description

predict to recruit 100 patients with pulmonary arterial hypertension (PAH)associated with CHD，under the commitment of the children's parents，take 3-4ml central venous blood before the corrective surgery，then calculate the number of the circulating endothelial cells by flow cytometer AND detect the expression of micro RNAs to screen out the biomarker，through the 6 months follow-up, separated the reversible and irreversible PAH,then to carry on the statistics.

Enrollment: 30 patients

Sex: All

Ages: 1 month to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Only those patients with systolic PAP (sPAP) >65mmHg before surgery were included.

Exclusion criteria

• Patients with trisomy 21 (Down syndrome) were not included

Trial design

30 participants in 2 patient groups

reversible PAH group

Description:

reversible PAH was defined as sPAP decreasing to 40 mmHg after follow-up more than 6 months through echocardiography.

irreversible PAH group

Description:

irreversible PAH was defined as 6 months after surgery through echocardiography ，the sPAP remaining 40 mmHg or up