The Search for Viral and Bacterial Etiology of Varicocele (ViBaVa)

Medical University of Warsaw

Status: Unknown

Conditions: VEGF Expression; Sonic Hedgehog Expression; Viral Infection; Varicocele; Bacterial Infections

Treatments: Procedure: subinguinal microscopic varicocelectomy; Procedure: open hernia repair

Study type: Interventional

Funder types: Other

Identifiers

NCT03079609

ViBaVa

Details and patient eligibility

About

This study is to answer the question is there any relationship between viral ( HSV 1 , HSV 2 , HPV 6/11, CMV, HHV 6 , HHV 8, BKV) or bacterial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum) infection and occurrence of varicocele in men.

Enrollment: 40 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• in experimental arm - varicocele grade II or III and infertility and/or pain

Exclusion criteria

• in control arm: presence of varicocele in ultrasound before surgery

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

microsurgery urology

Experimental group

Description:

20 patients with varicocele (grade II or III) undergoing subinguinal microsurgery varicocelectomy due to infertility and/or pain in the scrotum.

Treatment:

Procedure: subinguinal microscopic varicocelectomy

open general surgery

Active Comparator group

Description:

20 patients (without varicocele) undergoing open hernia repair.

Treatment:

Procedure: open hernia repair