The Secretion of Incretin Hormones in Patients With Polycystic Ovary Syndrome

Shanghai Jiao Tong University

Status: Unknown

Conditions: Polycystic Ovary Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02126592

12XJ10015

Details and patient eligibility

About

Polycystic ovary syndrome (PCOS) is an endocrine disease in reproductive women. It is characterized by anovulation and hyperandrogenism. Most patients with PCOS have metabolic abnormalities such as dyslipidemia, insulin resistance and glucose abnormalities. Almost 60-80﹪PCOS patients are obesity which exacerbates IR and hyperandrogenism. Obese PCOS patients tend to be overeating suggests that impaired appetite regulation might be contribute to the pathophysiology of PCOS. Our study is trying to observe difference of incretin between PCOS and normal control to figure out whether change of incretin is involved in the pathophysiology of PCOS.

Enrollment: 100 estimated patients

Sex: Female

Ages: 13 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women at reproductive age
• women with PCOS and women without PCOS

Exclusion criteria

• young women who had their menarche less than 3 years
• women older than 45 years old, Amenorrhea of menopause, hyperglycemia, hyperthyroidism, hypothyroidism, heart failure, lung failure, renal failure, anemia, dystrophy, gonitis

Trial design

100 participants in 2 patient groups

PCOS cohort

Description:

Women with PCOS

Control cohort

Description:

Women without PCOS