The SENTRY Study: Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer

Utah System of Higher Education (USHE)

Status: Enrolling

Conditions: Ovarian Cancer

Treatments: Diagnostic Test: Platelet RNA expression

Study type: Observational

Funder types: Other

Identifiers

NCT06665945

HCI175150

Details and patient eligibility

About

The purpose of the SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer. Using retrospective data, the investigators have developed an approach that appears to accurately classify ovarian cancer with relatively high sensitivity and specificity. The SENTRY Study will build upon these retrospective analyses to prospectively recruit women with ovarian cancer or an ovarian mass (and healthy control women), obtain platelet RNA samples from whole blood, and perform validation analyses to test our hypothesis.

Enrollment: 245 estimated patients

Sex: Female

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Study Population 1: Women with a Recent Diagnosis of Ovarian Cancer (n=90)

Inclusion Criteria:

1. Women aged 21 years or older
2. Diagnosed with any stage or type of ovarian cancer within the last 8 weeks

Exclusion Criteria:

1. Any other active malignancy
2. Other diagnosis of any cancer within the last 6 months
3. Treatment for any cancer within the last 6 months
4. History of ovarian cancer at any time
5. Currently receiving chemotherapy for ovarian cancer
6. Has already undergone complete ovarian mass resection
7. Unable to provide blood sample

Study Population 2: Control Women without Ovarian Cancer (n=30)

Inclusion Criteria:

1. Women aged 21 years or older

Exclusion Criteria:

1. Any active malignancy or diagnosis of cancer within the last 6 months
2. Treatment for any cancer within the last 6 months
3. Hospitalization or surgery (other than minor surgery such as mole removal) within the last 8 weeks
4. Renal failure (defined as eGFR < 60 mL/min/1.73m² or on dialysis)
5. Liver failure (defined as having hepatic encephalopathy of any degree, OR moderately severe coagulopathy defined as INR ≥ 1.5, OR known cirrhosis, OR ALT of ≥ 10X ULN, OR total bilirubin of ≥ 3.0 mg/dL, OR diagnosis of liver failure)
6. Decompensated or end-stage heart failure (defined as ACC/AHA Stage C or Stage D heart failure)
7. Poorly controlled diabetes mellitus (defined as a HbA1c > 9.0%)
8. Venous thrombosis, myocardial infarction, or stroke within the last 8 weeks
9. Currently pregnant or have been pregnant within the last 12 weeks
10. Any blood product transfusion within the last 8 weeks
11. Personal history of ovarian cancer at any time
12. History of bilateral salpingo-oophorectomy
13. History of oophorectomy
14. Unable to provide blood sample

Study Population 3: Women with a Recent Diagnosis of Ovarian Mass (n=125)

Inclusion Criteria:

1. Women aged 21 years or older
2. Diagnosed with any type of ovarian mass within the last 8 weeks

Exclusion Criteria:

1. Any diagnosis of active malignancy
2. Any diagnosis of any cancer within the last 6 months
3. Treatment for any cancer within the last 6 months
4. History of ovarian cancer at any time
5. Currently receiving chemotherapy for ovarian cancer
6. Has already undergone complete ovarian mass resection
7. Unable to provide blood sample

Trial design

245 participants in 3 patient groups

Women with a Recent Diagnosis of Ovarian Cancer (n=90)

Treatment:

Diagnostic Test: Platelet RNA expression

Women with a Recent Diagnosis of Ovarian Mass (n=125)

Treatment:

Diagnostic Test: Platelet RNA expression

Control Women without Ovarian Cancer (n=30)

Treatment:

Diagnostic Test: Platelet RNA expression