The Serotonergic Transmitter System in Dementia and Affective Disorders

Rigshospitalet

Status: Unknown

Conditions: Alzheimer Disease; Mood Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT00192998

SERT-AD

Details and patient eligibility

About

The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Moderate to severe Alzheimer's disease
• Individuals genetically predisposed to affective disorder
• Healthy gender and age matched controls

Exclusion criteria

• Contraindications to magnetic resonance imaging (MRI)
• Use of psychoactive drugs
• Past or present affective disorder
• Other systemic diseases that may affect brain function