The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis (uveitis)

Ozlem Sahin

Status: Unknown

Conditions: Sarcoidosis; Tuberculosis

Treatments: Other: radial immunodiffusion; Other: spectrophotometric assay

Study type: Interventional

Funder types: Other

Identifiers

NCT02627209

DGH-070

Details and patient eligibility

About

This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.

Full description

Increased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. Sarcoidosis, ankylosing spondylitis and Behcet's disease are the most common autoimmune inflammatory diseases involving the eye.

Elevated serum angiotensin converting enzyme levels have also been reported in tuberculosis. Syphilis and tuberculosis are the most common infectious diseases involving the eye.

Enrollment: 280 estimated patients

Sex: All

Ages: 9 to 86 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects have ocular inflammation diagnosed as sarcoidosis, ankylosing spondylitis, behcet's disease
• Subjects have ocular infection diagnosed as tuberculosis and syphilis
• Subjects have refractive errors only

Exclusion criteria

• Subjects using ACE inhibitors, systemic steroids, immunosuppressive or immunomodulatory therapies

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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280 participants in 2 patient groups

serum angiotensin converting enzyme

Active Comparator group

Description:

spectrophotometric assay

Treatment:

Other: radial immunodiffusion

Other: spectrophotometric assay

serum lysozyme

Active Comparator group

Description:

radial immunodiffusion

Treatment:

Other: radial immunodiffusion

Other: spectrophotometric assay