The Short-term Efficacy of Gastrodia and Uncaria Drink in Treating Hypertension

Shanghai Institute of Hypertension

Status and phase: Unknown; Phase 4

Conditions: Masked Hypertension

Treatments: Drug: Gastrodia and Uncaria Drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02156024

JDZX2012115

Details and patient eligibility

About

The purpose of this study is

1. To determine whether the Gastrodia and Uncaria Drink is effective in the treatment of masked hypertensive patients below 70 years.
2. To find out the suitable groups for the Gastrodia and Uncaria Drink treatment.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 18 to 70 years
• didn't use any anti-hypertension drugs within 2 weeks
• stage 1 masked hypertensive patients, which means clinic blood pressure<140/90 mmHg,however the daytime(8:00-18:00) 24h ambulatory blood pressure between 135/85 and 150/95mmHg
• be willing to participate in the trials and able to finish clinic visit

Exclusion criteria

• secondary hypertension
• be allergic to the clinical trial medicine
• occurrence of stroke, CKD, myocardial infarction within 2 years
• dysfunction of liver or kidney and fundus hemorrhage
• arrhythmia
• ALT, AST, TBL upper the twice of normal range, Scr≥2.0mg/dl, K+≥5.5mmol/L, Urine protein≥2+
• psychiatric disorders
• pregnant, breastfeeding
• other serious conditions in which is not fit for the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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400 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Description:

placebo drink, 1 dose at a time, twice a day, duration: 4 weeks

Gastrodia and Uncaria Drink

Active Comparator group

Description:

Gastrodia and Uncaria Drink, 1 dose at a time, twice a day, duration: 4 weeks

Treatment:

Drug: Gastrodia and Uncaria Drink